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Developing Potent Antivirals Is the ‘Direction of the Future’, Fauci Says

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Developing Potent Antivirals Is the ‘Direction of the Future’, Fauci Says

Dr. Anthony S. Fauci said on Monday the next phase in the fight against Covid-19 is developing “potent antivirals” that directly act on the SARS-CoV-2 virus.

The bottom line of what we need to do looking forward, and the clear need in this is the development of potent antivirals directly acting on SARS-CoV-2, very similar to what was done with the highly successful drug development program for H.I.V., as well as for Hepatitis C. And what I refer to as the future development of therapeutics will be based on the identification of vulnerable targets in the SARS-CoV-2 replication cycle, and the design of drugs to inhibit these vulnerable targets. As I mentioned, we are beginning this, and this is going to be the direction of the future. Baricitinib and remdesivir have earned emergency use authorization and a number of immunomodulators, including those that block a variety of cytokines and cytokine receptors, are currently in clinical trials. The F.D.A. will give guidance to how these companies can address a problem that we know is with us already, and that will be a problem in the future.

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